A tumor refers to an abnormal lesion formed by a clonal abnormal proliferation of a certain cell in a local tissue under the action of various carcinogenic factors, which loses normal growth regulation at the gene level. In academia, tumors are generally divided into two categories: benign tumors and malignant tumors.
Oncogenes and tumor suppressor genes can cause malignant transformation of cells when they are mutated, deleted or inactivated, leading to tumorigenesis. Therefore, studying the molecular mechanism of tumorigenesis and development, and exploring oncogenes and tumor suppressor genes and their signaling pathways in different tumors and their subtypes can provide molecular markers for early diagnosis of tumors and molecular targets for drug development.It is of great theoretical and clinical significance to explore the molecular mechanism of tumor recurrence and metastasis from the gene level by using omics technology.The theory of origin of tumorig enesis mainly has some proposed theories, which can be analyzed and discussed by using big data of tumor genome. Stem cell differentiation produces some premises and mature cell populations.
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