Target-related Tumors Research

A tumor is an abnormal lesion formed by a cell in a local tissue that loses its normal regulation of its growth at the gene level under the action of various carcinogenic factors. Tumors are generally classified into two categories, benign and malignant. Common tumor treatment methods include Chinese medicine treatment, combination of chemotherapy and immunotherapy, anti-angiogenesis treatment, magnetic field treatment and music therapy. Creative Proteomics provides advanced tumor research methods based on tumor characteristics and modern advanced biological technology, which can greatly help tumor treatment.

Target-related Tumors Research

1. Sample and: tissue, blood, cell sample acquisition;

2. Screening and verification of targets and related signal pathways;

3. Functional omics verification of candidate targets and downstream pathway screening;

4.Study on the signal pathways and action mechanisms of cell-level targets;

5.Signal pathways and action mechanisms of animal-level targets;

6. Detection of fine regulatory relationship between target and upstream and downstream target molecules;

7. Establishment of drug screening model and drug screening.

Method display

1. Sample and: tissue, blood, cell sample acquisition;

Target-related Tumors Research


Target-related Tumors Research

2. Screening and verification of targets and related signal pathways:

1) Target screening: various chips, second-generation sequencing, etc.

2) Signal pathway: correlation analysis, such as lncRNA, microRNA detection, etc .;

3) Verification: in vitro verification and in vivo verification;


3. Functional omics verification of candidate targets and downstream pathway screening:

1) Cell level For specific targets, gain of function / loss of function is used to clarify the function of the target and the relationship with the tumor at the cell level;

2) Animal level Related research through KI / KO animal models;

Target-related Tumors Research


Target-related Tumors Research

4. Study on the signal pathways and action mechanisms of cell-level targets:

1) Through high-throughput screening (chips, proteomics, pull-down, yeast hybrids, literature, etc.) to further identify target upstream and downstream promoters, miRNA, LncRNA, and autophagy related genes;

2) Through gain of function / loss of function, verify the clear upstream and downstream relationship between the target and related molecular pathways at the cell level;


5.Signal pathways and action mechanisms of animal-level targets:

1) Prove a clear upstream and downstream relationship between the target and related molecular pathways through specific signaling pathway agonists / inhibitors

2) Further prove the relationship between the target and related molecular pathways through the gene gain of function / loss of function, and clarify the upstream and downstream relationships (Tg / KO mouse);

Target-related Tumors Research


Target-related Tumors Research

6. Detection of fine regulatory relationship between target and upstream and downstream target molecules:

1) Interaction between proteins: through Co-IP, pull-down, FRET;

2) Upstream and downstream transcriptional regulation: through promoter-luciferase system, EMSA, etc.

3) For more elaborate molecular interaction areas: study the interaction domains through mutations and truncated bodies, such as the search for fine domains of protein-protein interactions.


7. Establishment of drug screening model and drug screening:

Identify the molecular mechanisms of tumor targets and their related pathways, and establish a specific tumor drug screening model based on the characteristics of the target and its downstream signaling pathways, and use the high-throughput screening platform (HTS) to perform specific drugs from the compound library Filter.

Target-related Tumors Research


Creative Proteomics leads a rich team that uses the most rigorous experimental solutions and internationally recognized experimental techniques for Target-related Tumors Research to obtain your customized information. Use the most accurate experimental results to help you better carry out tumor-related scientific research.

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Our advantage

Mature and reliable Target-related Tumors Research platform: rich project experience, participate in major projects, and publish high-level cooperation results.

The analysis contents and methods based on high-quality data analysis, pre-research and verification are indeed mature and feasible.

Please contact us to find out how we can help you achieve the next research breakthrough.

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