The resistance of tumor cells to chemotherapeutics is the main reason for the failure of chemotherapy. In vivo and in vitro studies have found that the molecular mechanism of tumor resistance is complex, including target gene mutation, target gene amplification, differences in DNA damage repair ability, and drug entering tumor cells The reduction of the internal concentration, etc., studying the drug mechanism of tumor drugs and the mechanism of tumor resistance can better help doctors to solve the problem of drug resistance in actual chemotherapy and the development of new drugs by medical researchers.
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