Tumor mutation burden (TMB) is the number of somatic mutations in the coding region of the tumor genome. It is an emerging biomarker that is related to the response to immunotherapeutics. Recent studies have shown that a high tumor mutation burden or burden increases the likelihood that immunogenic neoantigens expressed by tumor cells may induce a response to immunotherapy.
Next-generation sequencing (NGS) can help researchers estimate TMB, identify new antigens, study innovative therapies to enhance the immune response, and understand how genetic variation affects its efficacy. The characterization of expressed neoantigens will also facilitate the development of vaccines and cell-based therapies.
Creative Proteomics leads a rich team that uses the most rigorous experimental solutions and internationally recognized experimental techniques for Tumor mutations and neoantigens Solutions to obtain your customized information. Use the most accurate experimental results to help you better carry out tumor-related scientific research.
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3. Garofalo A, Sholl L, Reardon B, et al. The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine. Genome Med. 2016.
4. Buchhalter I, Rempel E, Endris V, et al. Size Matters: Dissecting Key Parameters for Panel-Based Tumor Mutational Burden (TMB) Analysis. Int J Cancer. 2018.